Saturn in this house gives an uncanny love for seclusion. You are likely to be mentally mature and have a philosophical bent of mind. Unless you love staying alone for long, this can be quite an unfavorable placement of Saturn for the native. Saturn in 12th house gives a lot of troubles, brought upon by circumstances or people. Sometimes, their health may go downhill due to some chronic disease. They may have to face frequent hospitalization.
At others, they may be victim to imprisonment or losses due to others. Such a person is likely to be involved in human welfare and service somehow. But they will be in an occupation where they work from the back end. On the other hand, there could also be a strong desire to escape societal pressures and live on your own. The person has the capability to acquire higher knowledge of spiritual and social realms.